Hydrochloric Acid → HCID 18616050, compound

HRID 1263410Notes

Reaction equation

HRID 1263410 reaction equation
NC1[S:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([O:13]C)=[O:12])=[C:7]([CH3:15])[C:5]=2[N:6]=1.[OH-].[K+].Cl.[N:19]([O-])=O.[Na+]>>[CH3:15][C:7]1[C:5]2[N:6]=[N:19][S:3][C:4]=2[CH:10]=[CH:9][C:8]=1[C:11]([OH:13])=[O:12]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 22390084Methyl 2-amino-4-methylbenzo[d]thiazole-5-carboxylateHCID 23668193Sodium Nitrite

Product 1

HCID 18616050HCID 18616050, compound

Procedure

5 g of methyl 2-amino-4-methylbenzothiazole-5-carboxylate (0.02 mol) in 28.6 g of 50% strength KOH were stirred at 120° C. for 4 h. The mixture was then neutralized with 10% strength HCl and admixed with an excess of 40% strength NaNO2 solution at 0-10° C. The reaction mixture was acidified and extracted with ethyl acetate. The extract was washed and dried, and the product was obtained by stripping off the solvent. Yield: 1.3 g (28%).

Workup

  1. customat 0-10° C
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed
  4. customdried
  5. customthe product was obtained

Sources & evidence

ORD record
ord-a509b02e3a3f405cbd0d8736dc9d3848
Source dataset
uspto-grants-2003_04
Patent number
US06541423B1

Reaction notes

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