反应详情

A mixture of (8(a)) (0.60 g), allyl bromide (0.28 g), potassium carbonate (0.59 g) and DMF (20 ml) was stirred for 3 hours at ambient temperature under an argon atmosphere. The dimethyl formamide was then evaporated under reduced pressure and the residue dissolved in ethyl acetate (50 ml) and water (50ml). The organic phase was separated, washed with brine (50 ml), dried over magnesium sulphate and evaporated under reduced pressure to dryness to give 3-(N-methyl-allyloxycarbamoyl)-5-nitro-benzoic acid allyl ester (8(b)) as a yellow oil (0.571 g).

1. customThe dimethyl formamide was then evaporated under reduced pressure
2. dissolutionthe residue dissolved in ethyl acetate (50 ml)
3. customThe organic phase was separated
4. washwashed with brine (50 ml)
5. dry with materialdried over magnesium sulphate
6. customevaporated under reduced pressure to dryness