Hydrochloric Acid → HCID 18617416, compound

HRID 1264073Notes

Reaction equation

HRID 1264073 reaction equation
[CH2:1]([NH:8][CH2:9][C:10]1[CH:47]=[CH:46][C:13]([CH2:14][N:15]2[C:19]3[CH:20]=[CH:21][C:22]([O:24][Si](C(C)(C)C)(C)C)=[CH:23][C:18]=3[N:17]=[C:16]2[C:32]2[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][N:41]3[CH2:45][CH2:44][CH2:43][CH2:42]3)=[CH:34][CH:33]=2)=[CH:12][C:11]=1[O:48][CH3:49])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:50]>O>[ClH:50].[ClH:50].[CH2:1]([NH:8][CH2:9][C:10]1[CH:47]=[CH:46][C:13]([CH2:14][N:15]2[C:19]3[CH:20]=[CH:21][C:22]([OH:24])=[CH:23][C:18]=3[N:17]=[C:16]2[C:32]2[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][N:41]3[CH2:42][CH2:43][CH2:44][CH2:45]3)=[CH:34][CH:33]=2)=[CH:12][C:11]=1[O:48][CH3:49])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12052638HCID 12052638, compound

Product 1

HCID 18617416HCID 18617416, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the benzyl amine (Example 4, Part A; 20 mg, 0.03 mmol) was added 6 N HCl (1 mL) and the mixture stirred at room temperature for 1 h. The solution was diluted with 5 mL of H2O, washed with Et2O, and the aqueous layer concentrated under reduced pressure; yielding 17 mg (89%) of the desired product.

Workup

  1. washwashed with Et2O
  2. concentrationthe aqueous layer concentrated under reduced pressure

Sources & evidence

ORD record
ord-001ae290f6544dd48a0e3d92574081be
Source dataset
uspto-grants-2003_04
Patent number
US06541499B1

Reaction notes

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