反应详情

Methyl 4-hydroxybenzoate (5.0 g, 32.86 mmol) was combined with 1,2-dibromoethane (35 mL) and potassium carbonate (6.8 g, 49.23 mmol, 1.5 eq.) then heated at reflux for 18 h. The reaction mixture was concentrated under reduced pressure then the residue partitioned between ethyl ether (500 mL) and water (200 mL). The ether was extracted with 2 N sodium hydroxide (5×50 mL). The solvent was removed under reduced pressure to give the desired product as a white solid (8.47 g, 99%).

1. temperaturethen heated
2. temperatureat reflux for 18 h
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe residue partitioned between ethyl ether (500 mL) and water (200 mL)
5. extractionThe ether was extracted with 2 N sodium hydroxide (5×50 mL)
6. customThe solvent was removed under reduced pressure