Water → HCID 18618217, compound

HRID 1264159Notes

Reaction equation

HRID 1264159 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Br:5][C:6]1[C:7]([NH:15][CH:16]=[N:17][OH:18])=[C:8]([C:11]([O:13]C)=O)[S:9][CH:10]=1.O>O1CCCC1.N1C=CC=CC=1.CN1CCCC1=O>[C:1]([O:18][N:17]1[C:11](=[O:13])[C:8]2[S:9][CH:10]=[C:6]([Br:5])[C:7]=2[N:15]=[CH:16]1)(=[O:3])[CH3:2]

Participants

7

Reactant 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 178499311HCID 178499311, compound

Product 1

HCID 18618217HCID 18618217, compound

Reagents, catalysts & solvents 3

HCID 1049PyridineSolventHCID 8028TetrahydrofuranSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

To a solution of acetyl chloride (0.234 g) in dry tetrahydrofuran (3 ml) was added a solution of the product from Example 4 (0.741 g) in pyridine (0.237 g) and N-methylpyrrolidone (5 ml) at room temperature. The solution was stirred at room temperature for 3 days and then poured into water (15 ml). The resulting precipitate was filtered, washed with water and dried to give title product, m.p. 159-162° C.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-7945d5e880af40ffbbb7ae4e7801cece
Source dataset
uspto-grants-2003_04
Patent number
US06541630B1

Reaction notes

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