Hydrazine hydrate (1:1) → HCID 18618216, compound

HRID 1264161Notes

Reaction equation

HRID 1264161 reaction equation
[NH2:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]([O:10]C)=O.O.[NH2:13][NH2:14]>C(O)CCC>[NH2:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]([NH:13][NH2:14])=[O:10]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 123584Methyl 3-amino-4-methylthiophene-2-carboxylate

Product 1

HCID 18618216HCID 18618216, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of methyl 3-amino-4-methyl-2-thenoate (25 g) and hydrazine hydrate (20 ml) in butanol (150 ml) was heated under reflux for 18 hours. On cooling the solvent was removed and teh residue was recrystallised from toluene to give the title product, m.p. 141-143° C.

Workup

  1. temperatureunder reflux for 18 hours
  2. temperatureOn cooling the solvent
  3. customwas removed
  4. customteh residue was recrystallised from toluene

Sources & evidence

ORD record
ord-eb84bb2ec50947fca003ae0fc60f3ea0
Source dataset
uspto-grants-2003_04
Patent number
US06541630B1

Reaction notes

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