P-Cresol → HCID 9839430, compound

HRID 1264338Notes

Reaction equation

HRID 1264338 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[CH:9]([OH:15])(O)[C:10]([F:13])([F:12])[F:11]>>[F:11][C:10]([F:13])([F:12])[CH:9]([C:1]1[CH:2]=[C:3]([CH3:8])[CH:4]=[C:5]([CH:9]([OH:15])[C:10]([F:13])([F:12])[F:11])[C:6]=1[OH:7])[OH:15]

Participants

3

Reactant 2

HCID 2879P-CresolHCID 679012,2,2-Trifluoro-1,1-ethanediol

Product 1

HCID 9839430HCID 9839430, compound

Conditions

Temperature
105 °C

Procedure

5.8 g (50 mmol) of p-cresol and 15.5 g (100 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 5 g of MgO are added. The mixture is heated at 105° C. for 8 hours. After treating according to the protocol described in Example 1, 70% of dihydroxyalkylated product are obtained.

Workup

  1. additionAfter treating
  2. customare obtained

Sources & evidence

ORD record
ord-46e55bb80a1e48e386306b47c3c87c93
Source dataset
uspto-grants-2003_04
Patent number
US06541674B2

Reaction notes

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