4-Chlorophenol → HCID 10220179, compound

HRID 1264339Notes

Reaction equation

HRID 1264339 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH:9](O)([OH:14])[C:10]([F:13])([F:12])[F:11]>>[F:11][C:10]([F:13])([F:12])[CH:9]([C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[OH:8])[OH:14]

Participants

3

Reactant 2

HCID 46844-ChlorophenolHCID 679012,2,2-Trifluoro-1,1-ethanediol

Product 1

HCID 10220179HCID 10220179, compoundYield 45%

Conditions

Temperature
100 °C

Procedure

12.5 g (100 mmol) of p-chlorophenol and 3.9 g (25 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 6 g of hydrotalcite Mg6AlGa(O4)16.4H2O are added and the mixture is heated at 100° C. for 7 hours. After treating the reaction medium according to the protocol described in Example 1, a yield of 45% of the expected product is obtained.

Workup

  1. additionAfter treating
  2. customthe reaction

Sources & evidence

ORD record
ord-9b9e601f333741c58e8bfd9c00b364a5
Source dataset
uspto-grants-2003_04
Patent number
US06541674B2

Reaction notes

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