反应详情

1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one (18.3 g) in a hot mixture of isopropanol (90 ml) and water (18.3 ml) was treated with concentrated hydrochloric acid (6.25 ml). The hot mixture was filtered and the filtrate diluted with isopropanol (90 ml) and stirred at room temperature for 17 h, cooled to 20 and the solid filtered off (21.6 g). A sample (6 g) was recrystallised from a mixture of water (6 ml) and isopropanol (10 ml) to give the title compound as a white crystalline solid (6 g) m.p. 178.5-179.50.

1. filtrationThe hot mixture was filtered
2. additionthe filtrate diluted with isopropanol (90 ml)
3. temperaturecooled to 20
4. filtrationthe solid filtered off (21.6 g)
5. customA sample (6 g) was recrystallised from a mixture of water (6 ml) and isopropanol (10 ml)