4-Bromophenacyl bromide → HCID 18613905, compound

HRID 1264950Notes

Reaction equation

HRID 1264950 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[Br:14][C:15]1[CH:24]=[CH:23][C:18]([C:19](=O)[CH2:20]Br)=[CH:17][CH:16]=1>>[Br:14][C:15]1[CH:24]=[CH:23][C:18]([C:19]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[S:3][CH:20]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613905HCID 18613905, compoundYield 73%

Procedure

In the same manner as in Example 74, methyl 4-thiocarbamoylbenzoate was reacted with 4-bromophenacyl bromide to obtain methyl 4-[4-(4-bromophenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 73%. Colorless prisms. Melting point: 206 to 207° C.

Sources & evidence

ORD record
ord-cc6092ac34104869bcb4eb3ecc8dc4a7
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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