反应详情

A mixture of ethyl 3-[4-(3,4-dimethylphenyl)-2-thiazolyl]benzoate (1.25 g), a 1N aqueous solution of sodium hydroxide (10 ml), tetrahydrofuran (10 ml) and ethanol (10 ml) was stirred at 60 to 70° C. for 1 hour. The reaction mixture was poured into 1N hydrochloric acid, and precipitated crystals were collected by filtration, and then washed with water. The product was recrystallized from acetone-hexane to obtain 3-[4-(3,4-dimethylphenyl)-2-thiazolyl]benzoic acid (825 mg, yield: 72%). Colorless prisms. Melting point: 235 to 236° C.

1. customprecipitated crystals
2. filtrationwere collected by filtration
3. washwashed with water
4. customThe product was recrystallized from acetone-hexane