HCID 86585899, compound → HCID 86585900, compound

HRID 1265360Notes

Reaction equation

HRID 1265360 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[C:6]([N+:9]([O-])=O)[C:5]([N:12]2[C:16](=[O:17])[CH:15]3[CH2:18][CH2:19][CH:20]=[CH:21][CH:14]3[C:13]2=[O:22])=[C:4]([F:23])[CH:3]=1>C(O)(=O)C.C(OCC)(=O)C.[Fe]>[NH2:9][C:6]1[C:5]([N:12]2[C:16](=[O:17])[CH:15]3[CH2:18][CH2:19][CH:20]=[CH:21][CH:14]3[C:13]2=[O:22])=[C:4]([F:23])[CH:3]=[C:2]([Cl:1])[C:7]=1[OH:8]

Participants

5

Reactant 1

HCID 86585899HCID 86585899, compound

Product 1

HCID 86585900HCID 86585900, compoundYield 107.6%

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 176Acetic AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

Iron powder (2.48 g) was added into a solution of 6-chloro-4-fluoro-2-nitro-3-(tetrahydrophthalimido)phenol (3.67 g) in acetic acid (60 ml) and stirred at room temperature for two hours. The reaction mixture was diluted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate, evaporated to give 3.6 g of the title compound.

Workup

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-779e008c25b64025951102170ff68b61
Source dataset
uspto-grants-2003_04
Patent number
US06545161B2

Reaction notes

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