Trifluoroacetic acid → HCID 18613404, compound

HRID 1265752Notes

Reaction equation

HRID 1265752 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]#[C:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][C:9]=1[NH:25][C:26](=[O:38])[CH2:27][C:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]#[N:37])[CH:31]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:15][N:14]([CH3:16])[C:12]1[C:11]([C:17]#[C:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][C:9]2[NH:25][C:26](=[O:38])[CH2:27][C:28]([C:30]3[CH:31]=[C:32]([CH:33]=[CH:34][CH:35]=3)[C:36]#[N:37])=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586802HCID 86586802, compound

Product 1

HCID 18613404HCID 18613404, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(3-cyano-phenyl)-3-oxo-propionyl-amino]-5-dimethylamino-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester (Example M4) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an orange solid (65 mg).

Sources & evidence

ORD record
ord-a761b1f10ce145e6b031e2a5e1630df6
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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