HRID1265755

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3nncc3COC3CCCCO3)c2)cc1-c1cccc(F)c1F

HCID86758913

未命名化合物

PRODUCTS

生成物

结构：CN(C)c1cc2c(cc1-c1cccc(F)c1F)NC(=O)CC(c1cccc(-n3nncc3CO)c1)=N2

HCID18613515

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared from (RS)-[2-dimethylamino-2′,3′-difluoro-5-(3-oxo-3-{3-[5-(tetrahydro-pyran-2-yloxymethyl)-[1,2,3]triazol-1-yl]-phenyl}-propionylamino)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example M7) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (26 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-13854f8acbba4129bfb718afbe718544
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06544985B2
来源说明: uspto-grants-2003_04

反应 SMILES

C(OC(=O)[NH:7][C:8]1[C:13]([NH:14][C:15](=[O:38])[CH2:16][C:17](=O)[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N:24]3C(COC4CCCCO4)=[CH:27][N:26]=[N:25]3)[CH:19]=2)=[CH:12][C:11]([C:39]2[CH:44]=[CH:43][CH:42]=[C:41]([F:45])[C:40]=2[F:46])=[C:10]([N:47]([CH3:49])[CH3:48])[CH:9]=1)(C)(C)C.[C:51]([OH:57])([C:53](F)(F)F)=O>C(Cl)Cl>[F:46][C:40]1[C:41]([F:45])=[CH:42][CH:43]=[CH:44][C:39]=1[C:11]1[C:10]([N:47]([CH3:49])[CH3:48])=[CH:9][C:8]2[N:7]=[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([N:24]4[C:53]([CH2:51][OH:57])=[CH:27][N:26]=[N:25]4)[CH:19]=3)[CH2:16][C:15](=[O:38])[NH:14][C:13]=2[CH:12]=1