Trifluoroacetic acid → HCID 18613294, compound

HRID 1265802Notes

Reaction equation

HRID 1265802 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:17][CH2:16][CH2:15]2)[C:11]([Cl:18])=[CH:10][C:9]=1[NH:19][C:20](=[O:32])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][N:27]=[C:26]([C:30]#[N:31])[CH:25]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:14]1([C:12]2[C:11]([Cl:18])=[CH:10][C:9]3[NH:19][C:20](=[O:32])[CH2:21][C:22]([C:24]4[CH:29]=[CH:28][N:27]=[C:26]([C:30]#[N:31])[CH:25]=4)=[N:7][C:8]=3[CH:13]=2)[CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586842HCID 86586842, compound

Product 1

HCID 18613294HCID 18613294, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-azetidin-1-yl-4-chloro-2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert. -butyl ester (Example M50) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an orange solid (66 mg).

Sources & evidence

ORD record
ord-50bf607ab9a94c61af86ca364fc9730c
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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