Trifluoroacetic acid → HCID 18613510, compound

HRID 1265813Notes

Reaction equation

HRID 1265813 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:45])[CH2:23][C:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[C:35]([CH2:36][O:37]C3CCCCO3)=[CH:34][O:33][N:32]=2)[CH:26]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][N:14]([CH3:15])[C:12]1[C:11]([C:17]([F:19])([F:18])[F:20])=[CH:10][C:9]2[NH:21][C:22](=[O:45])[CH2:23][C:24]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]4[C:35]([CH2:36][OH:37])=[CH:34][O:33][N:32]=4)[CH:26]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586853HCID 86586853, compound

Product 1

HCID 18613510HCID 18613510, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-dimethylamino-2-(3-oxo-3-{3-[4-(tetrahydro-pyran-2-yloxymethyl)-isoxazol-3-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester (Example M61) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (50 mg).

Sources & evidence

ORD record
ord-63e7f90a161044e3b7077b70fed961be
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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