Trifluoroacetic acid → HCID 18613196, compound

HRID 1265815Notes

Reaction equation

HRID 1265815 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:46])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[N:33]([CH3:45])[N:34]=[CH:35][C:36]=2[CH2:37][O:38]C2CCCCO2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:15][N:14]([CH3:16])[C:12]1[C:11]([C:17]([F:18])([F:20])[F:19])=[CH:10][C:9]2[NH:21][C:22](=[O:46])[CH2:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]4[N:33]([CH3:45])[N:34]=[CH:35][C:36]=4[CH2:37][OH:38])[CH:27]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586855HCID 86586855, compound

Product 1

HCID 18613196HCID 18613196, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-dimethylamino-2-(3-{3-[2-methyl-4-(tetrahydro-pyran-2-yloxymethyl)-2H-pyrazol-3-yl]-phenyl}-3-oxo-propionyl-amino)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester (Example M63) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (272 mg).

Sources & evidence

ORD record
ord-f80759d8681144acb55fad0d34b7f6f6
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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