Trifluoroacetic acid → HCID 18613410, compound

HRID 1265832Notes

Reaction equation

HRID 1265832 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([N:15]([CH3:17])[CH3:16])=[CH:10][C:9]=1[NH:18][C:19](=O)[CH2:20][C:21]([C:23]1C=C[CH:26]=[C:25]([C:29]#[N:30])[CH:24]=1)=O)(C)(C)C.[C:33](O)([C:35](F)(F)F)=[O:34]>C(Cl)Cl>[CH3:17][N:15]([CH3:16])[C:11]1[C:12]([CH3:14])=[CH:13][C:8]2[NH:7][C:33](=[O:34])[CH2:35][C:19]([C:20]3[CH:26]=[C:25]([CH:24]=[CH:23][CH:21]=3)[C:29]#[N:30])=[N:18][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586918HCID 86586918, compound

Product 1

HCID 18613410HCID 18613410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(3-Cyano-phenyl)-3-oxo-propionyl-amino]-4-dimethylamino-5-methyl-phenyl}-carbamic acid tert-butyl ester (Example M76) (0.24 g, 0.55 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a pale yellow solid (114 mg, 59%).

Sources & evidence

ORD record
ord-de8c677a3b0542b98a9c2593a42f6469
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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