Trifluoroacetic acid → HCID 18613474, compound

HRID 1265834Notes

Reaction equation

HRID 1265834 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([C:14]#[N:15])[C:11]([N:16]([CH3:18])[CH3:17])=[CH:10][C:9]=1[NH:19][C:20](=O)[CH2:21][C:22]([C:24]1C=C[CH:27]=[C:26]([C:30]#[N:31])[CH:25]=1)=O)(C)(C)C.[C:34](O)([C:36](F)(F)F)=[O:35]>C(Cl)Cl>[C:30]([C:26]1[CH:27]=[C:21]([C:20]2[CH2:36][C:34](=[O:35])[NH:7][C:8]3[CH:13]=[C:12]([C:14]#[N:15])[C:11]([N:16]([CH3:17])[CH3:18])=[CH:10][C:9]=3[N:19]=2)[CH:22]=[CH:24][CH:25]=1)#[N:31]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586919HCID 86586919, compound

Product 1

HCID 18613474HCID 18613474, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-cyano-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4-dimethylamino-phenyl}-carbamic acid tert-butyl ester (Example M78) (0.28 g, 0.63 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (36 mg, 59%).

Sources & evidence

ORD record
ord-46df6f3fefd74961a6da986a9db5044d
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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