Chloride → HCID 69688189, compound

HRID 1265876Notes

Reaction equation

HRID 1265876 reaction equation
[Cl:1][C:2]1[C:3]([N:27]([CH:29]([CH3:31])[CH3:30])[CH3:28])=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N:18]4[C:22](CO)=[CH:21][N:20]=[N:19]4)[CH:13]=3)[CH2:9][C:8](=[O:25])[NH:7][C:6]=2[CH:26]=1.S(Cl)(Cl)=O.[Cl-].[CH3:37][O:38][CH2:39][CH2:40][NH:41][CH3:42].Cl[CH2:44]Cl>CN(C=O)C>[Cl:1][C:2]1[C:3]([N:27]([CH:29]([CH3:31])[CH3:30])[CH3:28])=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N:18]4[C:22]([CH2:42][N:41]([CH2:40][CH2:39][O:38][CH3:37])[CH3:44])=[CH:21][N:20]=[N:19]4)[CH:13]=3)[CH2:9][C:8](=[O:25])[NH:7][C:6]=2[CH:26]=1

Participants

7

Reactant 5

HCID 312ChlorideHCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 300977(2-Methoxyethyl)(methyl)amineHCID 186131088-Chloro-4-[3-(5-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-7-(isopropyl-methyl-amino)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Product 1

HCID 69688189HCID 69688189, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from 8-chloro-4-[3-(5-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-7-(isopropyl-methyl-amino)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 96) (220 mg, 0.50 mmol) by reaction with thionylchloride in dichloromethane and subsequent treatment of the corresponding chloride with N-(2-methoxyethyl)methylamine in DMF according to the method described in Example 45. Obtained as a light yellow solid (120 mg, 47%).

Sources & evidence

ORD record
ord-ef6db3bfecf146d8b6c2de6a2ad3a115
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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