反应详情

A mixture of KCN (5.5 g, 84 mmol), m-trimethylsilylbenzylbromide (5.31 g, 21.8 mmol), tributylamine (0.11 g, 0.59 mmol) and water (12.5 cm3) was stirred overnight. The product was extracted with dichloromethane (3×30 cm3), the extract was filtered through a silica plug (5g) and the solvent was removed under reduced pressure. The residue was distilled to give the product (2.27 g, 55%) as a colorless liquid.

1. extractionThe product was extracted with dichloromethane (3×30 cm3)
2. filtrationthe extract was filtered through a silica plug (5g)
3. customthe solvent was removed under reduced pressure
4. distillationThe residue was distilled