Water → HCID 137178912, compound

HRID 1266180Notes

Reaction equation

HRID 1266180 reaction equation
[N:1]([O-:3])=O.[Na+].[CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)C=C[C:6]=1[CH:15]([C:22]([CH:24]([C:35]1[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=1)C1C=CC2C(=CC=CC=2)C=1)=[O:23])[C:16]1C=CN=CC=1.O>Cl>[OH:3][N:1]=[C:24]([C:35]1[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=1)[C:22]([C:15]1[CH:6]=[CH:5][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:16]=1)=[O:23]

Participants

5

Reactant 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 54540895HCID 54540895, compound

Product 1

HCID 137178912HCID 137178912, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

NaNO2 (0.35 g, 5 mmol) was added to a suspension of the product of step (b) above, (0.98 g, 4 mmol), in 3N HCl (20 mL), and H2O (20 mL). The slurry was stirred for 3 hours, filtered, washed with water, air dried to give the title compound. MS(ES) m/e 277 [M+H]+.

Workup

  1. filtrationfiltered
  2. washwashed with water, air
  3. customdried

Sources & evidence

ORD record
ord-156efc7ce94c42eea15a81d4f7e6ceab
Source dataset
uspto-grants-2003_04
Patent number
US06548503B1

Reaction notes

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