Dimethylformamide → HCID 18551166, compound

HRID 1266426Notes

Reaction equation

HRID 1266426 reaction equation
C([O:3][C:4](=[O:24])[C:5]([OH:23])([C:19]([F:22])([F:21])[F:20])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][C:11]=1[O:17][CH3:18])([CH3:9])[CH3:8])C.[CH3:25][N:26](C)C=O>[C-]#N.[Zn+2].[C-]#N>[C:25]([C:13]1[CH:14]=[CH:15][C:10]([C:7]([CH3:8])([CH3:9])[CH2:6][C:5]([OH:23])([C:19]([F:22])([F:20])[F:21])[C:4]([OH:3])=[O:24])=[C:11]([O:17][CH3:18])[CH:12]=1)#[N:26]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 17935641HCID 17935641, compound

Product 1

HCID 18551166HCID 18551166, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

From 4-(4-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester, zinc cyanide and tetrakis-triphenylphosphine-palladium in dimethylformamide at 140° C. After saponification, the title acid is obtained as an amorphous powder.

Workup

  1. customat 140° C

Sources & evidence

ORD record
ord-12a9e318fc1d450ba59325c1d2d2b1a4
Source dataset
uspto-grants-2003_04
Patent number
US06548534B2

Reaction notes

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