Hydrochloric Acid → HCID 18551811, compound

HRID 1266560Notes

Reaction equation

HRID 1266560 reaction equation
Cl.[CH2:2]([S:9][C:10]1[S:11][CH:12]([CH2:16][OH:17])[CH:13](O)[N:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[CH2:2]([S:9][C:10]1[S:11][C:12]([CH2:16][OH:17])=[CH:13][N:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11065016HCID 11065016, compound

Product 1

HCID 18551811HCID 18551811, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

0.2 ml of concentrated hydrochloric acid is added to 3.0 g of 2-benzylsulfanyl-5-hydroxymethyl-4,5-dihydrothiazol-4-ol in 25 ml of ethanol. The mixture is stirred at 50° C. for 12 hours, the solvent is removed in vacuo, and the residue is chromatographed on silica gel (ether:hexane; 1:1). The title compound is obtained in the form of a yellow oil (compound 3.1).

Workup

  1. customthe solvent is removed in vacuo
  2. customthe residue is chromatographed on silica gel (ether:hexane; 1:1)

Sources & evidence

ORD record
ord-c5ff8bb421c248809d0c3333e6399d37
Source dataset
uspto-grants-2003_04
Patent number
US06548676B1

Reaction notes

Loading…