Pyrrole → HCID 18548846, compound

HRID 1266733Notes

Reaction equation

HRID 1266733 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH:8]=1)[NH2:7].[NH:12]1[CH:16]=[CH:15][CH:14]=[CH:13]1.[OH-].[K+]>CS(C)=O>[N+:9]([C:5]1[CH:4]=[CH:3][C:2]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)=[CH:8][C:6]=1[NH2:7])([O-:11])=[O:10]

Participants

5

Reactant 3

HCID 8027PyrroleHCID 14797Potassium HydroxideHCID 742185-Chloro-2-nitroaniline

Product 1

HCID 18548846HCID 18548846, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from 5-chloro-2nitroaniline (1.73 g, 10 mmol), pyrrole (2.8 mL, 40 mmol) and KOH (85%, 990 mg, 15 mmol) in DMSO (8.6 mL) at 80° C. for 24 h according to the general procedure E (method a). Obtained as a brown solid (1.52 g).

Sources & evidence

ORD record
ord-1ad2b1eff3c54c12bda0cc64ab7ee066
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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