Stannous chloride dihydrate → (2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester

HRID 1266749Notes

Reaction equation

HRID 1266749 reaction equation
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][S:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[N+:24]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:15][CH2:16][S:17][CH2:18][CH2:19]2)[C:11]([C:20]([F:21])([F:22])[F:23])=[CH:10][C:9]=1[NH2:24])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69781296HCID 69781296, compound

Product 1

HCID 69780198(2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester

Procedure

The title compound was prepared from (2-nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example B2) (1.2 g, 2.95 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a yellow solid (978 mg).

Sources & evidence

ORD record
ord-70adc6cbc2e74bdfbd5dad2c29e07eff
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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