Stannous chloride dihydrate → (2-Amino-4-cyano-5-morpholin-4-yl-phenyl)-carbamic acid tert-butyl ester

HRID 1266753Notes

Reaction equation

HRID 1266753 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]#[N:21])=[CH:10][C:9]=1[N+:22]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[C:11]([C:20]#[N:21])=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69780848(4-Cyano-5-morpholin-4-yl-2-nitro-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 69779753(2-Amino-4-cyano-5-morpholin-4-yl-phenyl)-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from (4-cyano-5-morpholin-4-yl-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example B3) (5.01 g, 14.4 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a pink solid (4.18 g, 91%).

Sources & evidence

ORD record
ord-e0ae79dcdd4c47e8930c6df21315dfad
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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