Stannous chloride dihydrate → (2-Amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

HRID 1266755Notes

Reaction equation

HRID 1266755 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([C:15]([F:17])([F:18])[F:16])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69489376(5-Chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 69489727(2-Amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example A11) (7.00 g, 20.5 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a yellow solid (3.13 g, 49%).

Sources & evidence

ORD record
ord-2728bbb274964a0589eda19b39c089f1
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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