Trifluoroacetic acid → HCID 18548755, compound

HRID 1266828Notes

Reaction equation

HRID 1266828 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:37])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][N:32]=[C:31]([C:35]#[N:36])[CH:30]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:14]1([C:12]2[C:11]([C:20]([F:22])([F:23])[F:21])=[CH:10][C:9]3[NH:24][C:25](=[O:37])[CH2:26][C:27]([C:29]4[CH:34]=[CH:33][N:32]=[C:31]([C:35]#[N:36])[CH:30]=4)=[N:7][C:8]=3[CH:13]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586966HCID 86586966, compound

Product 1

HCID 18548755HCID 18548755, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-5-morpholin-4-yl-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester (Example M2) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (11 mg).

Sources & evidence

ORD record
ord-5ef7119f68c24b479b90e283dde49fa2
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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