Trifluoroacetic acid → HCID 18548814, compound

HRID 1266846Notes

Reaction equation

HRID 1266846 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[CH:15]2)=[CH:10][C:9]=1[NH2:19])(C)(C)C.CC1(C)O[C:26](=[O:28])[CH:25]=[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]3[O:36][CH:37]=[CH:38][N:39]=3)[CH:30]=2)O1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:36]1[CH:37]=[CH:38][N:39]=[C:35]1[C:31]1[CH:30]=[C:29]([C:24]2[CH2:25][C:26](=[O:28])[NH:19][C:9]3[CH:10]=[C:11]([N:14]4[CH:18]=[CH:17][CH:16]=[CH:15]4)[CH:12]=[CH:13][C:8]=3[N:7]=2)[CH:34]=[CH:33][CH:32]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 18548749HCID 18548749, compoundHCID 69488996(2-Amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 18548814HCID 18548814, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert.-butyl ester (Example J2) (137 mg) and 2,2-dimethyl-6-(3-oxazol-2-yl-phenyl)-[1,3]dioxin-4-one (Example L5) (271 mg) according to the general procedure M. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (83 mg).

Sources & evidence

ORD record
ord-b7df72da1497447e9f71d9994e28cdd4
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Reaction notes

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