Anisole → HCID 18545439, compound

HRID 1267087Notes

Reaction equation

HRID 1267087 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15]/[CH:16]=[CH:17]/[C:18]3[CH:19]=[N:20][N:21]([C:24]4[N:29]=[C:28]([NH:30]CC5C=CC(OC)=CC=5)[N:27]=[C:26]([NH:40]CC5C=CC(OC)=CC=5)[N:25]=4)[C:22]=3[CH3:23])[CH2:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[ClH:1].[NH2:40][C:26]1[N:27]=[C:28]([NH2:30])[N:29]=[C:24]([N:21]2[C:22]([CH3:23])=[C:18](/[CH:17]=[CH:16]/[CH2:15][N:12]3[CH2:13][CH2:14][N:9]([C:4]4[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([Cl:1])[CH:3]=4)[CH2:10][CH2:11]3)[CH:19]=[N:20]2)[N:25]=1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 59928271HCID 59928271, compound

Product 1

HCID 18545439HCID 18545439, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture consisting of 1.26 g of the compound obtained in Example 54, 50 ml of trifluoroacetic acid, and 0.62 ml of anisole was treated in the same manner as in Example 37 to obtain 420 mg of the title compound.

Workup

  1. additionwas treated in the same manner as in Example 37

Sources & evidence

ORD record
ord-044d617092a145c8bfd177894f907215
Source dataset
uspto-grants-2003_04
Patent number
US06552018B1

Reaction notes

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