反应详情

To a suspension of magnesium (0.69 g) in Et2O (5 mL) containing a trace of iodine was added dropwise a solution of 1-bromo4-isopropyl-benzene (5.97 g) in Et2O (50 mL). Following the addition, the mixture was heated under reflux for 1 hour. The resulting grignard solution was then carrefully added to a solution of 2-(2,4-dimethoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole (3.52 g) in THF (60 mL) and the mixture was stirred at room temperature for 16 hours. The reaction mixture was then poured into saturated aqueous solution of NH4Cl and the mixture was extracted with Et2O, dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by flash chromatography eluting with CH2Cl2/AcOEt (85/15) to give the title compound (3.5 g) as a pale yellow oil.

1. additionthe addition
2. temperaturethe mixture was heated
3. temperatureunder reflux for 1 hour
4. extractionthe mixture was extracted with Et2O
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customevaporated under reduced pressure
8. customThe residue was purified by flash chromatography
9. washeluting with CH2Cl2/AcOEt (85/15)