反应详情

To a stirred solution of 4-[4-(3-cyano-benzyl)-piperazin-1-yl]-phenylamine (400 mg), 6-methyl-4′-trifluoromethyl-biphenyl-2-carboxylic acid (460 mg), HOBt (222 mg), and Et3N (166 mg) in CH2Cl2 (20 mL) was added at room temperature EDCl (315 mg) and the mixture was stirred at room temperature for 16 hours. The organic solution was then washed with water, with a saturated solution of NaHCO3 and dried over Na2SO4. After filtration and evaporation of the filtrate, the residue was purified by flash chromatography eluting with CH2Cl2/MeOH (98/2) and crystallized from AcOEt to give the title compound (122 mg) as white crystals.

1. washThe organic solution was then washed with water, with a saturated solution of NaHCO3
2. dry with materialdried over Na2SO4
3. filtrationAfter filtration and evaporation of the filtrate
4. customthe residue was purified by flash chromatography
5. washeluting with CH2Cl2/MeOH (98/2)
6. customcrystallized from AcOEt