反应详情

A degassed solution of 8-bromoquinoline (1.0 g, 4.81 mmol) (Aldrich) in dioxane (50 mL)/H2O (10 mL) was treated with phenylboronic acic (0.64 g, 5.29 mmol) (Aldrich), Pd(Ph3P)4 (0.050 g, 0.04 mmol) and K2CO3 (0.73 g, 5.29 mmol). After refluxing for 4 hours under a N2 atmosphere the reaction was allowed to cool, diluted with EtOAc and separated. After drying over Na2SO4 and SiO2 chromatography (95:5 Hexanes/EtOAc) the titled compound was isolated as a colorless oil.

1. temperatureAfter refluxing for 4 hours under a N2 atmosphere the reaction
2. temperatureto cool
3. customseparated
4. dry with materialAfter drying over Na2SO4 and SiO2 chromatography (95:5 Hexanes/EtOAc) the titled compound
5. customwas isolated as a colorless oil