Carbon tetrabromide → HCID 23500559, compound

HRID 1267224Notes

Reaction equation

HRID 1267224 reaction equation
O[CH2:2][CH2:3][CH2:4][CH:5]1[N:11]2[C:12](=[O:15])[O:13][N:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1.C(Br)(Br)(Br)[Br:17].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:17][CH2:2][CH2:3][CH2:4][CH:5]1[N:11]2[C:12](=[O:15])[O:13][N:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 9815732HCID 9815732, compound

Product 1

HCID 23500559HCID 23500559, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product of Example 11 in methylene chloride at 0° C. is added carbon tetrabromide and triphenylphosphine. The reaction is stirred for 2 hours and the solvent is removed under reduced pressure. The crude product is dissolved in an eluting solvent system and chromatographed to afford the title compound.

Workup

  1. customthe solvent is removed under reduced pressure
  2. dissolutionThe crude product is dissolved in an eluting solvent system
  3. customchromatographed

Sources & evidence

ORD record
ord-0ce58ad626d94b07abee9280696ba581
Source dataset
uspto-grants-2003_04
Patent number
US06552052B2

Reaction notes

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