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HRID1267596

反应详情

EQUATION

反应方程式

HRID 1267596 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)CCC12OCCO2
HCID10902872

(4′S)-4′-Ethyl-7′,8′-dihydro-4′-hydroxyspiro[1,3-dioxolane-2,6′(3′H)-[1H]pyrano[3,4-f]indolizine]-3′,10′(4′H)-dione

C15H17NO6

PRODUCTS

生成物

1
结构：CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)CCC1=O
HCID10220900

(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

C13H13NO5

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To 90 ml of 90% trifluoroacetic acid, 3.5 g of (4S)-4-ethyl-6,6-(ethylenedioxy)-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,10(4H)-dione were added at room temperature over 5 minutes, followed by stirring at the same temperature for 30 minutes. After completion of the reaction, the solvent was removed under reduced pressure, followed by the thorough removal of the solvent by a vacuum pump. To the residue so obtained was added 20 ml of ethyl acetate. The crystals precipitated were collected by filtration, whereby 2.4 g of the title compound were obtained.

WORKUP

后处理

  1. customAfter completion of the reaction
  2. customthe solvent was removed under reduced pressure
  3. customfollowed by the thorough removal of the solvent by a vacuum pump
  4. customTo the residue so obtained
  5. customThe crystals precipitated
  6. filtrationwere collected by filtration