3-Pyridinecarbonyl chloride, hydrochloride (1:1) → Hydrochloric Acid

HRID 1267664Notes

Reaction equation

HRID 1267664 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].Cl.[C:27]([Cl:35])(=[O:34])[C:28]1[CH:33]=[CH:32][CH:31]=[N:30][CH:29]=1>>[C:27]([N:23]1[CH2:24][CH2:25][N:20]([CH2:19][C:17]2[CH:16]=[CH:15][N:14]=[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=2)[CH2:21][CH2:22]1)(=[O:34])[C:28]1[CH:33]=[CH:32][CH:31]=[N:30][CH:29]=1.[ClH:35]

Participants

4

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 120211551-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazine

Product 2

HCID 313Hydrochloric AcidHCID 18546845N-nicotinoyl-N'-[[2-(3,4,5-trimethoxyphenyl)-pyridin-4-yl]methyl]piperazine

Procedure

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) and nicotinic acid chloride hydrochloride (70 mg) were reacted in the same manner as in Example 46 to obtain the title compound as a hydrochloride.

Sources & evidence

ORD record
ord-2444bad2beab4b38a62f0209b0e231ee
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

Loading…