N-Acetyl-DL-methionine (HCID 6180)

Names & identifiers

Preferred name: N-Acetyl-DL-methionine
IUPAC: 2-acetamido-4-methylsulfanylbutanoic acid
English name: N-Acetyl-DL-methionine
Molecular formula: C7H13NO3S
Molecular weight: 191.25

Names & synonyms

N-Acetyl-DL-methionineMETHIONINE, N-ACETYL-RefChem:8288721115-47-5Ac-DL-Met-OHAcetyl-DL-methionineDL-Methionine, N-acetyl-DL-N-AcetylmethionineMethionine, N-acetyl-, DL-N-Acetylmethionine, DL-2-acetamido-4-methylsulfanylbutanoic aciddl-Acetylmethionine

Show more names

dl-methioninN-AC-DL-METMETHIONAMINEN-Ac-DL-Met-OHN-ACETYL-DL-METAC-DL-METHIONINEN-Ac-Dl-Methioninen-acetyl-dl-methioni

N-acetyl-D,L-methionineN-ACETYL-METHIONINE2-acetamido-4-methylsulfanyl-butanoic acid2-acetamido-4-(methylsulfanyl)butanoic acid383941IGXNNSC-76332-Acetamido-4-(methylthio)butanoic acidN-Acetyl(methyl)homocysteine

Database identifiers

CAS: 1115-47-5、65-82-7
PubChem CID: 6180
DTXSID: DTXSID5037022
ChEMBL: CHEMBL45002
ChEBI: CHEBI:132958
UNII: 383941IGXN
EC Number: 214-224-3

Properties

Computed structural properties

XLogP: 0.1
Topological polar surface area: 91.7 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 4
Rotatable bonds: 5
Heavy atoms: 12
Formal charge: 0
Complexity: 172

Physicochemical properties

Melting point: 117 · 117-119 °C(lit.)
Boiling point: 453.6 · 453.6±40.0 °C(Predicted)
Density: 1.2684 · 1.2684 (rough estimate)
refractive index: 1.637 · 1.6370 (estimate)
storage temp.: 2 · 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.5 · 3.50±0.10(Predicted)
color: White to Off-White
Water Solubility: Soluble in water, ethanol, ethyl acetate.
Merck: 14 · 14,96
BRN: 1725554 · 1725554
Major Application: peptide synthesis
Cosmetics Ingredients Functions: SKIN CONDITIONING
InChI: InChI=1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1
InChIKey: XUYPXLNMDZIRQH-LURJTMIESA-N
SMILES: C(O)(=O)[C@H](CCSC)NC(C)=O
CAS DataBase Reference: 1115 · 1115-47-5(CAS DataBase Reference)
FDA UNII: 383941 IGXN · 383941IGXN
EPA Substance Registry System: Methionine, N-acetyl- (1115-47-5)
UNSPSC Code: 41116107 · 41116107
NACRES: 24 · NA.24
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 318 · H318
Precautionary statements: 280 · P280-P305+P351+P338-P310
PPE: 95 · Eyeshields, Gloves, type N95 (US)
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36-24/25
WGK Germany: 3 · 3
RTECS: 500000 · PD0500000
TSCA: TSCA listed
HS Code: 29309070 · 29309070
Storage Class: 11 · 11 - Combustible Solids

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 66.7% (4 of 6) of all reports.

Danger

H318 (33.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 4 of 6 reports by companies.；There is 1 notification provided by 2 of 6 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory InformationN-Acetyl-DL-Methionine: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesEye Dam. 1 (33.3%)

Regulatory information

Regulatory InformationN-Acetyl-DL-Methionine: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE: Eyeshields, Gloves, type N95 (US)
wgk: 3
tsca: TSCA listed
rtecs: PD0500000
hs_code: 29309070
risk_code: 36/37/38
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: Xi
safety_code: 26-36-24/25
Storage Class: 11 - Combustible Solids
Hazard statements: H318
Precautionary statements: P280-P305+P351+P338-P310

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationMethionine, N-acetyl-: ACTIVE

Applications

DescriptionN-acetylmethionine is a methionine derivative that is methionine in which one of the amine hydrogens is substituted by an acetyl group.It is a conjugate acid of a N-acetylmethioninate.

UsesN-Acetyl-DL-methionine is used as pharmaceutical intermediate, biochemical reagent.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Additional notes · 1 item

DefinitionChEBI: N-acetylmethionine is a methionine derivative that is methionine in which one of the amine hydrogens is substituted by an acetyl group. It is a N-acyl-amino acid, a methionine derivative, a methyl sulfide and a monocarboxylic acid. It is a conjugate acid of a N-acetylmethioninate.