反应详情

To a solution of (3,4-difluorophenyl)-carbamic acid tert-butyl ester (Tetrahedron, (1992), 48(35), 7373) (15.1 g) in tetrahydrofuran (120 ml) at 0° C. was added potassium tert-butoxide (94 ml of a 1.0 M solution in tetrahydrofuran) dropwise. After stirring for 2 hr methyl bromoacetate (9.1 ml) was added dropwise and ice-bath removed and reaction mixture stirred at room temperature overnight. Reaction mixture concentrated under reduced pressure, diluted with ethyl acetate and washed with water and brine, dried (Na2SO4) and concentrated to leave the sub-title compound as a brown oil (18.0 g).

1. additionwas added dropwise
2. customice-bath removed
3. customreaction mixture
4. customReaction mixture
5. concentrationconcentrated under reduced pressure
6. additiondiluted with ethyl acetate
7. washwashed with water and brine
8. dry with materialdried (Na2SO4)
9. concentrationconcentrated