反应详情

To a solution of [tert-butoxycarbonyl-(3,4-difluorophenyl)-amino]-acetic acid methyl ester (14.7 g) in tetrahydrofuran (100 ml) was added water (100 ml) and lithium hydroxide monohydrate (6.2 g) and reaction mixture stirred at room temperature over-night before removal of tetrahydrofuran at reduced pressure. Residue was acidified to pH 4 by addition of KHSO4 (10% solution in water) and extracted with ethyl acetate. Organic extracts combined, dried (Na2SO4) and concentrated to leave the sub-title compound as a gum (12.3 g).

1. extractionextracted with ethyl acetate
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated