Tetrabutylammonium Fluoride → HCID 18542395, compound

HRID 1267932Notes

Reaction equation

HRID 1267932 reaction equation
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.C([Si](C)(C)[O:24][C:25]1[C:26]([CH3:44])=[C:27]([NH:31][C:32](=[O:43])[CH2:33][NH:34][C:35]2[CH:40]=[CH:39][C:38]([F:41])=[C:37]([F:42])[CH:36]=2)[CH:28]=[CH:29][CH:30]=1)(C)(C)C>C1COCC1>[F:42][C:37]1[CH:36]=[C:35]([NH:34][CH2:33][C:32]([NH:31][C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([OH:24])[C:26]=2[CH3:44])=[O:43])[CH:40]=[CH:39][C:38]=1[F:41]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 18542392HCID 18542392, compound

Product 1

HCID 18542395HCID 18542395, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of tetrabutylammonium fluoride in THF (1M, 4.6 ml) was added to a solution of the product from step (c) (1.71 g) in THF (20 ml). The mixture was stirred at room temperature for 1 hour and evaporated to dryness. The residue was purified by flash chromatography eluting with 3% ethanol (EtOH) in dichloromethane (CH2Cl2) to give the product as a white solid. Yield 0.82 g.

Workup

  1. customevaporated to dryness
  2. customThe residue was purified by flash chromatography
  3. washeluting with 3% ethanol (EtOH) in dichloromethane (CH2Cl2)

Sources & evidence

ORD record
ord-040e534bfeba41d292db5a5a38ae9a67
Source dataset
uspto-grants-2003_04
Patent number
US06555541B1

Reaction notes

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