Triphenylphosphine → 3-(2-Chloro-4-nitro-phenoxy)-1-methyl-pyrrolidine

HRID 1268017Notes

Reaction equation

HRID 1268017 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].[CH3:12][N:13]1[CH2:17][CH2:16][CH:15](O)[CH2:14]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>O1CCCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[O:11][CH:15]1[CH2:16][CH2:17][N:13]([CH3:12])[CH2:14]1

Participants

6

Reactant 4

HCID 11776TriphenylphosphineHCID 12074NitrofunginHCID 930741-Methyl-3-pyrrolidinolHCID 5462977Diethyl azodicarboxylate

Product 1

HCID 185429983-(2-Chloro-4-nitro-phenoxy)-1-methyl-pyrrolidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-chloro-4-nitrophenol (2.0 g) in tetrahydrofuran (60 mL) is added 1-methyl-3-pyrrolidinol (2.3 g), triphenyl phosphine (6.0 g), and diethylazodicarboxylate (3.6 mL) and the mixture is stirred at room temperature under an atmosphere of argon for 1.5 hours. The solution is then concentrated under reduced pressure, diluted with ethyl acetate, washed successively with 10% aqueous sodium hydroxide, water, saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is chromatographed over silica gel (ethyl acetate then 10% methanol in dichloromethane is used as the eluant). Pooled product fractions are then recrystallized from hexanes to provide the desired product as a yellow solid.

Workup

  1. concentrationThe solution is then concentrated under reduced pressure
  2. additiondiluted with ethyl acetate
  3. washwashed successively with 10% aqueous sodium hydroxide, water, saturated aqueous sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent is removed by evaporation under reduced pressure
  6. customthe residue is chromatographed over silica gel (ethyl acetate
  7. customPooled product fractions are then recrystallized from hexanes

Sources & evidence

ORD record
ord-dbfe9d954e564d5dbe591de7e3ea67bb
Source dataset
uspto-grants-2003_04
Patent number
US06555561B2

Reaction notes

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