反应详情

In a stream of nitrogen and at 0° C., 117 mg (1.04 mmol) of potassium t-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 200 mg (0.52 mmol) of 3-benzyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 1, and the mixture was stirred for 1 hour. Next, this solution was mixed with 0.16 ml (0.78 mmol) of decanoyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 150 mg (yield: 50.0%) of the title compound.

1. customproduced in Reference Example 1
2. stirringstirred at room temperature for 3 hours
3. customAfter completion of the reaction
4. customthe solvent was evaporated
5. extractionThe resulting residue was extracted with ethyl acetate
6. washwashed with water and saturated brine in that order
7. dry with materialdried over anhydrous sodium sulfate
8. customthe solvent was evaporated under a reduced pressure
9. customThe resulting residue was purified by a silica gel column chromatography