Hydrochloric Acid → HCID 18542818, compound

HRID 1268167Notes

Reaction equation

HRID 1268167 reaction equation
[ClH:1].Cl.Cl.[CH3:4][N:5]([CH2:19]/[CH:20]=[CH:21]/[C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([NH2:27])=[NH:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:8][CH:7]=1.Cl.[C:32](=[NH:37])(OCC)[CH3:33].C(N(CC)CC)C.Cl>CO.O1CCOCC1>[ClH:1].[ClH:1].[ClH:1].[C:32]([N:16]1[CH2:15][CH2:14][CH:13]([O:12][C:9]2[CH:10]=[CH:11][C:6]([N:5]([CH2:19]/[CH:20]=[CH:21]/[C:22]3[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=3)[C:25]([NH2:27])=[NH:26])[CH3:4])=[CH:7][CH:8]=2)[CH2:18][CH2:17]1)(=[NH:37])[CH3:33]

Participants

7

Reactant 4

HCID 313Hydrochloric Acid2×HCID 8471TriethylamineHCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)HCID 18542790HCID 18542790, compound

Product 1

HCID 18542818HCID 18542818, compoundYield 216.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 3-[3-[N-methyl-N-[4-(piperidin-4-yloxy)phenyl]amino]-1-(E)-propenyl]benzamidine trihydrochloride (368 mg) in methanol (20 ml) were added ethyl acetimidate hydrochloride (290 mg) and triethylamine (0.65 ml) at room temperature. The resulting mixture was stirred at room temperature for 12 hours. To the reaction mixture was added a 4M solution of hydrogen chloride in dioxane (1 ml) and the solution was concentrated in vacuo. The residue was purified by preparative HPLC (YMC-Pack ODS YMC) using 10% aqueous acetonitrile as an eluant to afford an amorphous solid. To a solution of the solid in methanol (10 ml) was added a 4M solution of hydrogen chloride in dioxane (0.5 ml) and the mixture was concentrated to dryness in vacuo. A solution of the residual solid in water (about 10 ml) was lyophilized to give the title compound (288 mg, yield 72%) as a pale brown amorphous solid.

Workup

  1. concentrationthe solution was concentrated in vacuo
  2. customThe residue was purified by preparative HPLC (YMC-Pack ODS YMC)
  3. customto afford an amorphous solid
  4. concentrationthe mixture was concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-7af4bc827b72420ab38f41b61c62d18b
Source dataset
uspto-grants-2003_04
Patent number
US06555556B1

Reaction notes

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