反应详情

To a solution of 5-cyano-2-hydroxycinnamaldehyde (2.3 g) in N,N-dimethylformamide (25 ml) were added methoxymethyl chloride (1.5 ml) and triethylamine (2.8 ml) in an ice bath and the mixture was stirred at room temperature for 1 hour. The reaction mixture was extracted with ethyl acetate. The extract was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and the filtrate concentrated in vacuo to give the desired compound (2.8 g, yield 98%) as a colorless solid.

1. extractionThe reaction mixture was extracted with ethyl acetate
2. washThe extract was washed with brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationthe filtrate concentrated in vacuo