Tributylphosphine → (E)-(S)-ethyl 2-ethoxy-3-{4-[3-(5'-isopropyl-2'-methoxy-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-propionate

HRID 1268265Notes

Reaction equation

HRID 1268265 reaction equation
C(P(CCCC)CCCC)CCC.[CH2:14]([O:16][C@@H:17]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:15].[CH:31]([C:34]1[CH:35]=[CH:36][C:37]([O:51][CH3:52])=[C:38]([C:40]2[CH:45]=[CH:44][C:43]([C:46]([CH3:50])=[CH:47][CH2:48]O)=[CH:42][CH:41]=2)[CH:39]=1)([CH3:33])[CH3:32]>C1C=CC=CC=1.O.C(OCC)(=O)C>[CH2:14]([O:16][C@@H:17]([CH2:23][C:24]1[CH:25]=[CH:26][C:27]([O:30][CH2:48]/[CH:47]=[C:46](/[C:43]2[CH:42]=[CH:41][C:40]([C:38]3[CH:39]=[C:34]([CH:31]([CH3:32])[CH3:33])[CH:35]=[CH:36][C:37]=3[O:51][CH3:52])=[CH:45][CH:44]=2)\[CH3:50])=[CH:28][CH:29]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:15]

Participants

7

Reactant 3

HCID 13831TributylphosphineHCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 697969353-(5'-Isopropyl-2'-methoxy-biphenyl-4-yl)-but-2-en-1-ol

Product 1

HCID 86589948(E)-(S)-ethyl 2-ethoxy-3-{4-[3-(5'-isopropyl-2'-methoxy-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-propionate

Reagents, catalysts & solvents 3

HCID 241BenzeneSolventHCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

Azodicarboxylic dipiperidide (0.756 g, 3.0 mmol) was added at 0-5° C. to a stirred solution of tributylphosphine (0.74 ml, 0.61 g, 3.0 mmol), (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (0.50 g, 2.10 mmol) and 3-(5′-isopropyl-2′-methoxy-biphenyl-4-yl)-but-2-en-1-ol (0.593 g, 2.0 mmol) in dry benzene (15 ml), the mixture warmed to room temperature, and stirred for 4 h. The resulting mixture was diluted with water (100 ml) and ethyl acetate (50 ml), the aqueous layer collected and further extracted with ethyl acetate (50 ml). The organic layers were combined, washed with brine, dried (MgSO4) and evaporated. The crude product was then purified by column chromatography on silica (10% ethyl acetate in n-heptane eluent) to give (E)-(S)-ethyl 2-ethoxy-3-{4-[3-(5′-isopropyl-2′-methoxy-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-propionate as a colourless oil; 0.67 g (65%).

Workup

  1. customthe aqueous layer collected
  2. extractionfurther extracted with ethyl acetate (50 ml)
  3. washwashed with brine
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customThe crude product was then purified by column chromatography on silica (10% ethyl acetate in n-heptane eluent)

Sources & evidence

ORD record
ord-0667d5d8508e400f83b1e6aa9c92ac79
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

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