Hydrochloric Acid → HCID 20288042, compound

HRID 126853Notes

Reaction equation

HRID 126853 reaction equation
CC([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH2:13][CH2:14][C:15](=[O:17])[CH3:16])[C:5]1=[O:18])=C.Cl>CC(O)C>[O:17]=[C:15]([CH3:16])[CH2:14][CH2:13][N:6]1[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:4][C:5]1=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 202880381,3-dihydro-1-(1-methylethenyl)-3-(3-oxobutyl)-2H-benzimidazol-2-one

Product 1

HCID 20288042HCID 20288042, compoundYield 73.4%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A mixture of 48.8 parts of 1,3-dihydro-1-(1-methylethenyl)-3-(3-oxobutyl)-2-H-benzimidazol-2-one, 12 parts of 2-propanol, saturated with gaseous hydrogen chloride and 240 parts of 2-propanol is stirred for 3 hours at room temperature. The precipitated product is filtered off, washed with 2,2'-oxybispropane and dried, yielding 30 parts (73.4%) of 1,3-dihydro-1-(3-oxobutyl)-2H-benzimidazol-2-one.

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed with 2,2'-oxybispropane
  3. customdried

Sources & evidence

ORD record
ord-b40f17870600447b951952ffed4052eb
Source dataset
uspto-grants-1981_03
Patent number
US04254127

Reaction notes

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