Hydrogen Bromide → HCID 20288044, compound

HRID 126868Notes

Reaction equation

HRID 126868 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][CH:15]3[CH2:20][CH2:19][N:18](C(OCC)=O)[CH2:17][CH2:16]3)OCC[O:10]2)[CH:6]=[CH:7][CH:8]=1.[BrH:26].CC(O)C>O>[BrH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9](=[O:10])[CH2:14][CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3776IsopropanolHCID 20288068HCID 20288068, compound

Product 1

HCID 20288044HCID 20288044, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 30 parts of ethyl 4-[2-(3-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-1-piperidinecarboxylate, 225 parts of a hydrobromic acid solution 48% in water and a small amount of 2-propanol is stirred and refluxed for 2 hours. The reaction mixture is cooled. The precipitated product is filtered off and dried, yielding 9.5 parts (30%) of 1-(3-methoxyphenyl)-2-(4-piperidinyl)ethanone hydrobromide.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitated product is filtered off
  4. customdried

Sources & evidence

ORD record
ord-602fa33ad1f045149cafdacadb08d45d
Source dataset
uspto-grants-1981_03
Patent number
US04254127

Reaction notes

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