Hydrochloric Acid → HCID 18446661, compound

HRID 1268749Notes

Reaction equation

HRID 1268749 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([NH:19][C:20]([C:22]3[CH:31]=[CH:30][C:25]([C:26]([O:28]C)=[O:27])=[CH:24][CH:23]=3)=[O:21])[S:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][N:14]=2)[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([NH:19][C:20]([C:22]3[CH:31]=[CH:30][C:25]([C:26]([OH:28])=[O:27])=[CH:24][CH:23]=3)=[O:21])[S:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][N:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18446666HCID 18446666, compound

Product 1

HCID 18446661HCID 18446661, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of methyl 4-[[[4-(3-methylphenyl)-5-(4-pyrimidinyl)-1,3-thiazol-2-yl]amino]carbonyl]benzoate (0.50 g, 1.2 mmol) in ethanol (10 mL) was added 2N aqueous sodium hydroxide solution (1.2 mL), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was acidified with 2N hydrochloric acid and the precipitated solids were collected by filtration. Crude crystals were washed with water and dried to give the title compound (0.40 g, yield 0.82%).

Workup

  1. filtrationthe precipitated solids were collected by filtration
  2. washCrude crystals were washed with water
  3. customdried

Sources & evidence

ORD record
ord-d1648e161f1e4e21a39789a57b7863a5
Source dataset
uspto-grants-2007_04
Patent number
US07199124B2

Reaction notes

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