Sodium hydride → HCID 86591437, compound

HRID 1268937Notes

Reaction equation

HRID 1268937 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.[H-].[Na+].CS(O[CH2:30][CH2:31][O:32][N:33]=[C:34]([C:36]1[CH:41]=[CH:40][C:39]([C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[CH:38][CH:37]=1)[CH3:35])(=O)=O>>[F:48][C:45]1[CH:44]=[CH:43][C:42]([C:39]2[CH:40]=[CH:41][C:36]([C:34](=[N:33][O:32][CH2:31][CH2:30][O:20][C:17]3[CH:16]=[CH:15][C:14]([CH2:13][CH:7]([O:6][C:5]4[CH:21]=[CH:22][C:2]([F:1])=[CH:3][CH:4]=4)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:19][CH:18]=3)[CH3:35])=[CH:37][CH:38]=2)=[CH:47][CH:46]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 18625989HCID 18625989, compoundHCID 74020541HCID 74020541, compound

Product 1

HCID 86591437HCID 86591437, compound

Procedure

The target compound (1.45 g) was obtained as a white powder by carrying out the reaction and the post-treatment according to Reference example 2 using ethyl 2-(4-fluorophenoxy)-3-(4-hydroxyphenyl)propionate (1.8 g) obtained from Reference example 25(b), sodium hydride (55%, 271 mg), and 2-[[1-(4′-fluoro-4-biphenylyl)ethylidene]aminoxy]ethyl methanesulfonate (2.14 g) obtained from Reference example 26(b).

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-18d5da8321a4460d8bd1850f622bad39
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

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